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Journal Club Global: Moving leiomyoma research from bench to bedside


Uterine leiomyomata are benign tumors that develop during the reproductive years with a 70-80% prevalence by menopause. While hysterectomy is definitive treatment, many women desire to preserve their potential fertility. Myomectomy is a useful surgical procedure for leiomyomas inside the uterine cavity. Medical therapies are available but are primarily temporary in effect and primarily act through decreasing estradiol action, leading to additional risks related to hypoestrogenism. Leiomyomas may return to pre-treatment size after medication discontinuation and most of these medical therapies are incompatible with patients attempting to achieve pregnancy. There is a need for non-hormonal, easily accessible, and affordable treatments for leiomyoma. This Journal Club Global discusses the article “Curcumin inhibits human leiomyoma xenograft growth and induces dissolution of extracellular matrix” recently published in F&S Science. Topics include: • What is curcumin? • How does curcumin mechanistically impact leiomyomas? • Discuss the pros and cons of 2-D, 3-D, and xenograft models in the laboratory study of human disease? • What is the data on other nutritional supplements for leiomyoma prevention or reduction? • What is the pathophysiology of leiomyoma growth and infertility?

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Fertility and Sterility

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F&S Reports

F&S Reports is an open-access journal that publishes peer-reviewed original scientific articles in clinical and translational research that have strong potential to transform clinical practice.

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F&S Reviews cover image
Journal

F&S Reviews

F&S Reviews publishes both systematic and comprehensive, authoritative review articles spanning reproductive medicine or science.

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F&S Science cover image
Journal

F&S Science

F&S Science publishes peer-reviewed original scientific articles in basic, laboratory, and translational research that has strong potential to transform clinical practice.

Read F&S Science
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