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Multiple Egg Donations Do Not Impair Donors' Future Fertility

October 16 , 2013
by: ASRM Office of Public Affairs
Published in ASRM Press Release

HIGHLIGHTS FROM THE INTERNATIONAL FEDERATION OF FERTILITY SOCIETIES  21st WORLD CONGRESS ON FERTILITY AND STERILITY AND THE  69th ANNUAL MEETING OF THE AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE

Researchers at Weill Cornell Medical College in New York City reviewed all egg donor charts from January 2004 to April 2012 to identify patients who had completed five or more egg donation cycles.  Records were examined for donors' starting Anti Mullerian hormone (AMH) levels, cycle characteristics - amount of hormonal medication and number of days medication was administered, and number of eggs retrieved.  The average patient age at first donation was 26.4 and, at fifth cycle, 28.7.

The researchers found that, although the starting dose of gonadotropin used to stimulate ovulation in the first cycle was significantly lower than that required in subsequent cycles, the total amount of gonadotropins used was comparable through multiple cycles.  The other measures were comparable, too, over five to six cycles, with average days required for stimulation ranging from 9.4 to 10 and the average number of eggs retrieved ranging from 20.9 to 23.8. 

"This retrospective study is reassuring in that egg donors who undergo up to 6 cycles do not have evidence of depleting their ovarian reserve, which bodes well for their future fertility" notes ASRM President Linda Giudice, MD, PhD. "It also underscores the importance of careful monitoring of egg donors prior to starting medication in order to minimize the risk of ovarian hyperstimulation syndrome."

O-378 Repetitive Oocyte Donation Does Not Affect Ovarian Reserve and Oocyte Yield
BA Levine et al
 

Representing more than 50 fertility societies from around the globe, the International Federation of Fertility Societies (IFFS) is the world’s principal international fertility organization. The IFFS was founded in 1951, and held its first congress in New York in 1953. The IFFS mission is to stimulate basic and clinical research, disseminate education and encourage superior clinical care of patients in infertility and reproductive medicine. Website: http://www.iffs-reproduction.org/ 

The American Society for Reproductive Medicine, founded in 1944, is an organization of more than 7,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.  Affiliated societies include the Society for Assisted Reproductive Technology, the Society for Male Reproduction and Urology, the Society for Reproductive Endocrinology and Infertility, the Society of Reproductive Surgeons and the Society of Reproductive Biologists and Technologists.


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