Preimplantation genetic testing for aneuploidy: Can non-invasive approaches based on spent medium analysis replace classical trophectoderm biopsy?

Presented in Partnership with Fertility and Sterility

PGT-A by trophectoderm biopsy aims to select available euploid embryos for transfer. While the clinical efficacy of PGT-A remains debated in the scientific literature, the possibility to conduct non-invasive PGT-A (ni-PGTA) has emerged from finding that acellular DNA can be collected in the spent culture medium and through blastocele aspiration. Efforts were thus developed to determine the genetic constitution of embryos from an analysis of acellular DNA collected in the spent medium.

The Journal Club Global discusses a Fertile Battle article recently published in Fertility and Sterility discussing the respective efficacy of classical trophectoderm biopsy and new ni-PGTA options.

Hosts Micah Hill and Dominique de Ziegler facilitate the discussion following the presentation of trophectoderm biopsy PGT-A by Paul Pirtea and ni-PGTA by Carmen Rubio. Additional discussantion includes experts in new ART developments including Catherine Racowsky, Laura Rienzi, and Richard T. Scott, Jr.

Questions and issues to be addressed during the event include:
  • Safety of trophectoderm biopsy
  • Respective validation of trophectoderm biopsy and ni-PGTA
  • Risks of systematic transfer of blastocysts on day 6
  • Optimal modalities of spent medium collection
Carmen Rubio, Ph.D.
Paul Pirtea, M.D.
Catherine Racowsky, Ph.D.
Laura Rienzi, Ph.D.
Richard Scott, M.D.

Dominique De Ziegler, M.D.
Micah Hill, D.O.

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