Grand Rounds: Clinical Pharmacology of Hormones

(Credits no longer offered.)

Presented by James H. Liu, M.D., Case Western Reserve University and University Hospitals, Case Medical Center

The American Board of Obstetrics and Gynecology has developed guidelines for learning for the subspecialty of reproductive endocrinology and infertility (REI). These guidelines specify that training in this subspecialty should include training in the clinical pharmacology of reproductive hormones. This live internet activity is designed to provide such training to reproductive endocrinology and infertility fellows as well as other practitioners of reproductive medicine. The presentation is designed to provide an overview of the bioavailability and kinetics of reproductive hormones and their synthetic analogs as well as different modes of drug delivery. The activity will consist of a didactic presentation followed by a question and answer session.

At the conclusion of the educational activity, participants should be able to:
  1. Define absorption, excretion, distribution, biotransformation, and bioavailability of drugs and hormones, showing knowledge of these mechanisms for transfer across membranes, into and across cells, storage, metabolism, and excretion.
  2. Define scope and limitation of different delivery systems for steroid and glycoprotein hormones.
  3. Discuss the production, availability, and advantages of recombinant glycoprotein hormones.

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