Prognosis in unexplained RPL: a systematic review and quality assessment of current clinical prediction models

Recurrent pregnancy loss is one of the bigger challenges in the field of reproductive medicine. This journal club will discuss the published systematic review that identified models predicting live birth or ongoing pregnancy in couples with unexplained recurrent pregnancy loss (RPL). The manuscript evaluates the risk of bias, performance, generalizability, and applicability of these models. Finding a good model with accurate predictors would manage the expectations of couples and improve their informed decision making regarding future pregnancy attempts. Please join us for a lively discussion where we review the current models for predicting live birth or ongoing pregnancy in couples with unexplained recurrent pregnancy loss (RPL) and evaluate promises and pitfalls of these predictors.