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DHEA Supplementation Improves Sexual Function in Older, Pre-Menopausal, Infertile Women

Note: All information is embargoed until the time of presentation at the Scientific Congress, unless otherwise indicated.

HIGHLIGHTS FROM THE AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE’S 2018 SCIENTIFIC CONGRESS & EXPO

Embargoed for Release: 12:01 am CDT Monday, October 8, 2018 

Contact:                     

Eleanor Nicoll - enicoll@asrm.org - 202-863-2439  (thru Oct 5) - 240-274-2209 mobile                    
Sean Tipton - stipton@asrm.org - 202-863-2494 (thru Oct 3)

Note: Press room open Sun. October 7, 2pm-5pm CDT; Mon. October 8-Wed. October 10 8:00am-5:30pm CDT.

DHEA Supplementation Improves Sexual Function in Older, Pre-Menopausal, Infertile Women

Denver, CO- Today, at the American Society for Reproductive Medicine’s Scientific Congress, researchers reported for the first time that poor sexual function in pre-menopausal women can be significantly improved by androgen supplementation with DHEA.

Poor sexual function has been reported to improve in post-menopausal women taking a DHEA supplement.  To investigate whether DHEA could also be effective in pre-menopausal women, the researchers recruited 50 infertility patients of advanced age (average age 41). The women received a 75 mg oral DHEA supplement daily.  Prior to, and again 4 to 8 weeks after initiating treatment, the women completed a questionnaire, the Female Sexual Function Index (FSFI), and underwent comprehensive hormone testing.

All the women’s serum androgen levels increased, while their FSH levels decreased.  The average FSFI score increased by 7%, with the score for desire, arousal, and lubrication increasing by 17%, 12%, and 8% respectively.  Average scores for orgasm, satisfaction and pain were unchanged.

It was the women whose FSFI scores were in the lowest quartile before starting DHEA supplementation who benefitted the most. Their FSFI scores increased 34% on average, with all domains improving: desire by 40%, arousal by 46%, lubrication by 33%, orgasm by 54%, satisfaction by 24%, and pain by 25%. The women in this quartile also experienced a much greater increase in their free testosterone levels compared to women in the highest-scoring quartile on the first FSFI.

Paula Amato, MD, a member of the ASRM Board of Directors noted, “DHEA supplementation may hold promise for improving sexual function for premenopausal women without infertility, as well.  Given that the study was not placebo controlled, more research is needed.”

O-49      EFFECTS OF DEHYDROEPIANDROSTERONE (DHEA) SUPPLEMENTATION ON SEXUAL FUNCTION IN OLDER PRE-MENOPAUSAL INFERTILE WOMEN.  V. A. Kushnir et al

 

 

ASRM is a multidisciplinary organization dedicated to the advancement of the science and practice of reproductive medicine. The Society accomplishes its mission through the pursuit of excellence in education and research and through advocacy on behalf of patients, physicians, and affiliated health care providers. The Society is committed to facilitating and sponsoring educational activities for the lay public and continuing medical education activities for professionals who are engaged in the practice of and research in reproductive medicine. www.asrm.org 


For more information on these press releases, contact: 

J. Benjamin Younger Office of Public Affairs 
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Contact

Eleanor Nicoll
Ph: 202-863-2349 or 240-274-2209 (mobile)
E: enicoll@asrm.org

Sean Tipton
Ph: 202-863-2494
E: stipton@asrm.org

 

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