View Our Top Three #ASRM2020 Plenaries - NOW FREE!
Nov 10, 2020
Origin: ASRM Announcement
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Preimplantation genetic testing for aneuploidy (PGT-A) with trophectoderm (TE) biopsy is widely applied in in vitro fertilization to identify aneuploid embryos. However, potential safety concerns regarding biopsy and restrictions to only those embryos suitable for biopsy pose limitations. In addition, embryo mosaicism gives rise to false positives and false negatives in PGT-A because the inner cell mass (ICM) cells, which give rise to the fetus, are not tested. We report a noninvasive preimplantation genetic testing for aneuploidy (niPGT-A) in the spent culture media by measuring the copy numbers of cell-free DNA from the ICM only. We also have demonstrated niPGT-A in the spent culture for monogenic and polygenic diseases by high-precision detection of point mutations in the cell free deoxyribonucleic acid (DNA) through linkage analyses.
A synopsis from the book written by the speaker, Andres Trevino, Andy & Sofia – Stem Cells, Scientific Miracles and One Fit Savior. In an incubated petri dish in a Boston laboratory, a cluster of eight living cells holds the key to a daring new era of medical science. These cells come from a human embryo containing genetic material from my wife Paulina and me, obtained through in vitro fertilization (IVF). Research using these cells holds enormous potential to cure a fatal disease, saving the lives of countless children and relieving their families of unspeakable pain. We lived that pain ourselves. When our son was born, we did not know what a tortuous road stretched ahead of us–how our baby would suffer, and how we would suffer with him.