Plenary Lecture 9 - SSR Exchange Lecture: Colony Stimulating Factor 2: Example of a Maternal Embryokine that Programs the Mammalian Embryo
Time:2:45 pm - 3:30 pm
Location:HCC310 - Hawaii Convention Center
Peter J. Hansen, Ph.D., University of Florida
SSR Exchange Lecture: Colony Stimulating Factor 2: Example of a Maternal Embryokine that Programs the Mammalian Embryo for Pregnancy Success
Needs Assessment and Description
Changes in the maternal environment during the preimplantation period can have short- and long-term effects on development that can extend into postnatal life. It is important to understand how specific molecules produced by the reproductive tract change the trajectory of development so that an optimal environment for the embryo can be established. This information is relevant for clinicians and allied health professionals involved in women’s health and assisted reproductive technologies.
At the conclusion of this session, participants should be able to:
- Explain how changes in the maternal environment during the preimplantation period can have short-term and long-term effects on development that can extend into postnatal life.
- Discuss the importance of the environment of the preimplantation embryo for its development.
- Describe how the actions of one maternally derived regulatory molecule, colony-stimulating factor 2, regulate development of the preimplantation embryo in a sex-dependent manner.
Treatment of the bovine preimplantation embryo with colony-stimulating factor 2 (CSF2) results in which of the following changes in development?
a. Increased number of inner cell mass cells and resistance to apoptotic signals
b. Reduced number of trophectoderm cells
c. Death by apoptosis
d. Activation of WNT signaling