Plenary Lecture 5 - Bariatric Surgery: It’s Not What You Think It Is

Date:October 21, 2014

Time:9:45 am - 10:30 am

Location:HCC Ballroom - Hawaii Convention Center


Randy J. Seeley, Ph.D., University of Cincinnati


Endowed by a 1990 grant from Astra-Zeneca

Bariatric Surgery: It’s Not What You Think It Is. Molecular Targets for the Beneficial Effects of Surgery on Obesity and Diabetes

Needs Assessment and Description
Various bariatric procedures do not simply cause weight loss but also exert powerful metabolic effects. Understanding how procedures differ in these effects is critical for physicians who must treat obese patients and the complications that come with their obesity, including reproductive problems.

Learning Objectives
At the conclusion of this session, participants should be able to:

  1. Describe the different effects of various bariatric procedures on metabolism and hormone secretion.
  2.  Identify key molecular mediators of the potent effects of bariatric surgery on weight and metabolism.

ACGME Competency
Medical Knowledge

A 34-year-old woman with a body mass index (BMI) of 38 kg/m2 was diagnosed with type II diabetes 2 years ago. Her hemoglobin A1c (HbA1c) is 8.5%, despite taking several diabetes drugs. She is considering either a vertical sleeve gastrectomy or gastric bypass surgery to lose weight. After participating in this session, in my practice I will tell this patient that she might expect the following from either procedure 1 year after the surgery:
a. Her HbA1c is not likely to be improved by either surgery.
b. Her HbA1c will be improved only if she has a gastric bypass.
c. Her HbA1c will be improved only if she has a vertical sleeve gastrectomy.
d. Her HbA1c will be improved after both surgeries.
e. Not applicable to my area of practice


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