GnRH Analogs

GnRH analogs are synthetic hormones similar to the naturally occurring gonadotropin releasing hormones (GnRH) produced by the hypothalamus. GnRH analogs, when given in short pulses, stimulate the pituitary gland to produce FSH and LH. However, when given in more prolonged doses, they decrease FSH and LH production by the pituitary, which in turn decreases ovarian hormone production. Brand names are Lupron®, Synarel®, and Zolodex®.


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