11-2013 Case of the Month

What would you do in this this case?

A patient who recently moved from another state comes to your clinic for transfer of her 3 cryopreserved embryos from a previous cycle. The embryos have been shipped to your center and are ready for thaw and transfer. Slow freezing was used for cryopreservation.

What do you do? 

A. Use a very high warming rate.
B. Utilize your laboratory’s standard warming protocol as that is what your laboratory personnel are most skilled with.
C. Obtain the thaw protocol from the clinic sending the embryos and follow it.
D. Increase the sucrose concentration in the thaw solutions.

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Answer A is incorrect: The warming protocol must match the cooling protocol. A high warming rate used with a slow cooling rate would be detrimental to the embryos. 

Answer B is incorrect: The warming protocol must match the cooling protocol; the incorrect warming rate would be detrimental to the embryos.

Answer C is CORRECT: Obtain the thaw protocol from the clinic sending the embryos and follow it.  

Answer D is incorrect: The sucrose concentration in the thawing medium must match the sucrose concentration in the freezing solution. The sucrose concentration must be reduced gradually to coincide with biologic fluids.

Learn more about this topic while earning CME at ASRM eLearn®.  

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