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In ART Cycles, Retrieval of More than 15 Eggs Leads to Increased Risk of Complications, But Only Minor Increase in Birth Rate

October 14 , 2013
by: ASRM Office of Public Affairs
Published in ASRM Press Release

HIGHLIGHTS FROM THE INTERNATIONAL FEDERATION OF FERTILITY SOCIETIES 21st WORLD CONGRESS ON FERTILITY AND STERILITY AND THE 69th ANNUAL MEETING OF THE AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE

In ART Cycles, Retrieval of More than 15 Eggs Leads to Increased Risk of Complications, But Only Minor Increase in Birth Rate 

Boston, MA – Using a comprehensive national data base of Assisted Reproductive Technology (ART) cycles in the U.S. between 2008 and 2010, researchers presenting at the International Federation of Fertility Societies/American Society for Reproductive Medicine meeting found that retrieval of more than 15 oocytes (or eggs) from a woman led to a greater risk of Ovarian Hyperstimulation Syndrome (OHSS), with only a nominal increase in live birth rate.

A team collaborating from multiple sites used the Society for Assisted Reproductive Technology (SART) IVF Registry to evaluate more than 250,000 ART cycles performed in the U.S. in 2008, 2009 and 2010. They categorized the cycles by number of eggs retrieved and found that moving from the 11-15 egg category to the 16-20 egg category increased the live birth rate from 39.3% to 42.7%,  and it raised the risk of OHSS from .93% to 1.67 %. In the highest category, more than 25 eggs retrieved, the live birth rate was 41.8% while the OHSS risk jumped to 6.34%.  The investigators state that as a result of this analysis, “it is time to reevaluate our strategy for multiple follicular recruitment in IVF.”

“This is exactly the kind of research that the SART database is most useful for. By examining a large number of cases, we are able to evaluate and improve the care provided to our patients,” said David Ball, PhD, President of the Society for Assisted Reproductive Technology.

O-8  The Risk for Ovarian Hyperstimulation Syndrome Significantly Increases and Live Birth Rates Plateau in Patients with >15 Oocytes Retrieved: An Analysis of 256,381 Fresh Autologous IVF Cycles.
 A.A. Shah et al
 

Representing more than 50 fertility societies from around the globe, the International Federation of Fertility Societies (IFFS) is the world’s principal international fertility organization. The IFFS was founded in 1951, and held its first congress in New York in 1953. The IFFS mission is to stimulate basic and clinical research, disseminate education and encourage superior clinical care of patients in infertility and reproductive medicine. Website: http://www.iffs-reproduction.org/ 

The American Society for Reproductive Medicine, founded in 1944, is an organization of more than 7,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.  Affiliated societies include the Society for Assisted Reproductive Technology, the Society for Male Reproduction and Urology, the Society for Reproductive Endocrinology and Infertility, the Society of Reproductive Surgeons and the Society of Reproductive Biologists and Technologists.


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