Interactive Session - Society for Assisted Reproductive Technology - PGD: The How and When
Time:1:15 pm - 2:15 pm
Location:Room 1 - San Diego Convention Center
G. David Ball, Ph.D. (Chair), Seattle Reproductive Medicine
Paul S. Dudley, M.D., Seattle Reproductive Medicine
William G. Kearns, M.D., Johns Hopkins University Medical Institutions
PGD: The How and When
Needs Assessment and Description
Embryo preimplantation genetic testing includes
preimplantation genetic screening (PGS) for aneuploidy
inversions. This live session will review all preimplantation
genetic technologies available today and discuss in which
clinical situations the use of these technologies is and is
not appropriate. The application of this technology, the
stage of embryo biopsy, whether one should perform a
fresh embryo transfer or a frozen/thaw cycle, the limitations
of this genetic technology, and how the results can be
interpreted and applied to patient care will be discussed.
The goal of this interactive session will be to open a dialogue
about the advantages and disadvantages of the varied
strategic approaches to offer preimplantation genetic
testing. This topic should have value for all members of
in vitro fertilization (IVF) programs considering or offering
preimplantation genetic testing to their patients.
At the conclusion of this session, participants should be able
- Identify the current strategies for PGD, including the best
stage for biopsy.
- Describe the limitations of current technologies.
- Discuss the future direction of these technologies.
Recent data document that approximately 65-70% of all first
trimester miscarriages are aneuploid. After participating in
this session, in my practice, for a couple undergoing IVF with
PGS, the following preimplantation genetic test would be
- Single-nucleotide polymorphism microarray for all
- Low-density comparative genomic hybridization
microarray for all chromosome pairs
- Quantitative real time polymerase chain reaction for all
- 10-12 probe fluorescence in situ hybridization
- Not applicable to my area of practice